Investigation of dsDNA Stretching Meso-Mechanics Using LS-DYNA
This paper proposes a novel mathematical model for studying the entropic elasticity and cooperative extensibility of double strand DNA (dsDNA) using LS-DYNA and equivalent theory. Through the proposed model, the dynamic structural transitions of the dsDNA under external force/torque can be accurately simulated within an affordable CPU time. Moreover, the proposed dsDNA model comprises the meso-mechanics equivalent theory of single molecule dsDNA, including the base-stacking interaction between DNA adjacent base pairs, the Hydrogen bond of complementary base-pairs and electrostatic interactions along double-helix sugar-phosphate backbones. Good agreement is achieved between the numerical simulation and the single molecular manipulation experimental result, and the mechanical behavior of stretching nicked dsDNA could be revealed.
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Investigation of dsDNA Stretching Meso-Mechanics Using LS-DYNA
This paper proposes a novel mathematical model for studying the entropic elasticity and cooperative extensibility of double strand DNA (dsDNA) using LS-DYNA and equivalent theory. Through the proposed model, the dynamic structural transitions of the dsDNA under external force/torque can be accurately simulated within an affordable CPU time. Moreover, the proposed dsDNA model comprises the meso-mechanics equivalent theory of single molecule dsDNA, including the base-stacking interaction between DNA adjacent base pairs, the Hydrogen bond of complementary base-pairs and electrostatic interactions along double-helix sugar-phosphate backbones. Good agreement is achieved between the numerical simulation and the single molecular manipulation experimental result, and the mechanical behavior of stretching nicked dsDNA could be revealed.
11-7.pdf
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